Run command won't start

[LavinaVRovine]

Hello,

I've encountered a problem I am having troubles to formulate, therefore I can't google it properly.

I have a script:
WheelLeft::
Run, "C:\Program Files\Microsoft Office\root\Office16\OUTLOOK.EXE", "C:\Program Files\Microsoft Office\root\Office16"
Return
+XButton1::
Send, !{Right}
Return

WheelRight::
Run, "C:\Users\pavel\AppData\Local\GPMDP_3\app-4.4.0\Google Play Music Desktop Player.exe"
Return

which works fine (if I output message for instance), but the RUN commands do not start from everywhere. For instance, it does not start when I am using Chrome, but works fine from FileExplorer.

Could anybody please point me to a resource about this kind of problem?

Thanks in advance