Hotstring option toggle by Hotkey?

[Techikatona]

Hi,
Is there a possibilty to combine Hotsrting settings with Hotkeys ?
(Without duplicating all hotstrings ofcourse And without adding extra lines to hotstrings)
I can imagine ways, but only by duplicating everything.

Reason:
I would like to use normal space to fire hotsring in a way, that the space is added at the end,
but i want to use Alt+Space if i want to use it as ":o:"
(Actually it would be very nice to know how in general how a Hotkey could be used to modify some #Options.)

Something like this:
#"if Alt is pressed"
{
#Hotkey o
}
::hlo::Hello!
::wtv::Whatever

Alternatively it could add a BS after the end, like:
~!space::send,{bs} ;(this does not work together with the hotsrting ofcourse)

Instead of something like this:
::hlo::
{
if alt is pressed...else ...
}